MetabolismThe brain consumes up to twenty percent of the energy used by the human body, more than any other organ. Brain metabolism normally is completely dependent upon blood glucose as an energy source, since fatty acids do not cross the blood-brain barrier. During times of low glucose (such as fasting), the brain will primarily use ketone bodies for fuel with a smaller requirement for glucose. The brain can also utilize lactate during exercise. The brain does not store any glucose in the form of glycogen, in contrast, for example, to skeletal muscle.
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